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Decoding lipid metabolic reprogramming in pancreatic ductal adenocarcinoma: from tumor–microenvironment crosstalk to therapeutic resistance

26/10/2026 · Thành viên: Bà. Nguyễn Thu Hồng · Nguồn: OpenAlex

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a nutrient-poor, hypoxic, and highly desmoplastic microenvironment that imposes substantial metabolic stress on malignant cells. Under th...

<p><strong>Tác giả:</strong> Xingyu Liu, Zitong Ye, Liuyang Wang, Yubo Chi, Tongjia Chu, Ziyu Liu, Shanxiang Yu, Haocheng Yang, Xinyue Yin, Jian Zhang, Alfred Wei Chieh Kow, Huan Liu</p>

<p>Pancreatic ductal adenocarcinoma (PDAC) is characterized by a nutrient-poor, hypoxic, and highly desmoplastic microenvironment that imposes substantial metabolic stress on malignant cells. Under these unfavorable conditions, lipid metabolism reprogramming provides cancer cells with the flexibility needed to maintain growth and survive therapeutic stress. Recent advances have uncovered new links between lipid metabolic reprogramming, the tumor microenvironment, and therapeutic resistance in PD...</p>

<p>📄 DOI: <a href="https://doi.org/https://doi.org/10.3389/fonc.2026.1977031" target="_blank" rel="noopener">https://doi.org/10.3389/fonc.2026.1977031</a></p>

<p>📖 <a href="https://doi.org/https://doi.org/10.3389/fonc.2026.1977031" target="_blank" rel="noopener">Xem bài báo đầy đủ</a></p>

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