Six new combretastatin A-4 derivatives containing a naphtho[2,3-b]thiophene-4,9-dione core were successfully synthesized via a two-step procedure. This approach involved a multi-component reaction...
<p><strong>Tác giả:</strong> Hoàng Thị Phương, Nguyễn Hà Thanh, Thi Nga Nguyen, Dang Thi Tuyet Anh, Giang Le-Nhat-Thuy, Nguyen Thi Quynh Giang, Dang Thi, Cao Thi Hue, Nguyen Tuan Anh, Thanh Tra Nguyen, Nguyen Van Tuyen</p>
<p>Six new combretastatin A-4 derivatives containing a naphtho[2,3-b]thiophene-4,9-dione core were successfully synthesized via a two-step procedure. This approach involved a multi-component reaction to generate dihydrofuranonaphthoquinone intermediates, followed by a sulfur-mediated oxidative transformation of the dihydrofuran scaffold into the corresponding thiophene derivatives. The structures of all synthesized compounds were characterized using IR, ¹H-NMR, and ¹³C-NMR spectroscopy. In vitro...</p>
<p>📄 DOI: <a href="https://doi.org/https://doi.org/10.25073/2588-1140/vnunst.6022" target="_blank" rel="noopener">https://doi.org/10.25073/2588-1140/vnunst.6022</a></p>
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