Background Busulfan is a cornerstone of conditioning regimens for pediatric allogeneic hematopoietic stem cell transplantation (HSCT), yet its narrow therapeutic index and high pharmacokinetic vari...
<p><strong>Tác giả:</strong> Yewei Chen, Wenjin Jiang, Ping Wang, Ling Yu, Xiaowen Qian, Guangfei Wang, Jie Cai, Mengdi Hu, Xiaowen Zhai, Zhiping Li</p>
<p>Background Busulfan is a cornerstone of conditioning regimens for pediatric allogeneic hematopoietic stem cell transplantation (HSCT), yet its narrow therapeutic index and high pharmacokinetic variability necessitate individualized dosing. This study aimed to develop and evaluate a population pharmacokinetic (PopPK) model for busulfan in Chinese pediatric allogeneic HSCT recipients, characterize the exposure-response relationship, and establish a model-informed precision dosing (MIPD) strateg...</p>
<p>📄 DOI: <a href="https://doi.org/https://doi.org/10.3389/fphar.2026.1974352" target="_blank" rel="noopener">https://doi.org/10.3389/fphar.2026.1974352</a></p>
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