Cardia gastric adenocarcinoma (CGA) is an aggressive malignancy with rising incidence and poor prognosis, driven in part by significant molecular heterogeneity. Through integrated bioinformatics an...
<p><strong>Tác giả:</strong> Wang Zhenxiang, Tian Tongguan, Chen Ying, Zhang Yan, Qian Meng, Sun Huihui, Yanping Xu, Shuchang Xu</p>
<p>Cardia gastric adenocarcinoma (CGA) is an aggressive malignancy with rising incidence and poor prognosis, driven in part by significant molecular heterogeneity. Through integrated bioinformatics and clinical analyses, we identify Latent-Transforming Growth Factor Beta-Binding Protein 2 (LTBP2) as a key heterogeneously expressed protein markedly upregulated in CGA compared to non-cardia gastric adenocarcinoma (NCGA), correlating with advanced tumor stage and reduced survival. Mechanistically,...</p>
<p>📄 DOI: <a href="https://doi.org/https://doi.org/10.1038/s41388-026-03965-9" target="_blank" rel="noopener">https://doi.org/10.1038/s41388-026-03965-9</a></p>
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