Abstract Background Obtaining target-specific therapeutic antibodies is critical for maximizing efficacy, yet conventional library-based approaches cannot guarantee epitope specificity or enable st...
<p><strong>Tác giả:</strong> Kairi Furui, Shinji Soga, Rika Yamazaki, Shigenori Yagi, K. Uchikawa, Takatsugu Kosugi, Takuya Shimomura, Kana Gondo, Masahito Ohue</p>
<p>Abstract Background Obtaining target-specific therapeutic antibodies is critical for maximizing efficacy, yet conventional library-based approaches cannot guarantee epitope specificity or enable straightforward humanization; computational de novo design of human antibodies targeting specific epitopes has therefore attracted increasing interest. Methods We developed SANDAN (Structure-Aware de Novo Design for ANtibody), an end-to-end, structure-driven workflow that uses the antigen structure an...</p>
<p>📄 DOI: <a href="https://doi.org/https://doi.org/10.1093/abt/tbag054" target="_blank" rel="noopener">https://doi.org/10.1093/abt/tbag054</a></p>
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